Author

L. Bastian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

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Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

C. D. Baldus· 3 shared A. M. Hartmann· 2 shared M. Neumann· 2 shared M. Schrappe· 2 shared A. Akalin· 1 shared A. Arner· 1 shared A. Burchert· 1 shared A. K. Bergmann· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCancer Biology

C. D. Baldus

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4 papers

Recent·Most cited

The gene expression classifier ALLCatchR identifies B-precursor ALL subtypes and underlying developmental trajectories across age

T. Beder, B.-T. Hansen, A. M. Hartmann, J. Zimmermann, E. Amelunxen, N. Wolgast, W. Walter, M. Zaliova, Z. Antic, P. Chouvarine, L. Bartsch, M. Barz, M. Bultmann, J. Horns, S. Bendig, , L. Bastian

ALLCatchR, a machine learning classifier, accurately assigns B-precursor ALL samples to molecular subtypes and identifies developmental trajectories using RNA-Seq data.

bioRxiv · Feb 1, 2023 · PreprintCancer Biology

IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

D. Das Gupta, C. Paul, N. Samel, M. Bieringer, D. Staudenraus, F. Marini, H. Raifer, L. Menke, L. Hansal, B. Camara, E. Roth, P. Daum, M. Wanzel, M. Mernberger, A. Nist, , M. Lohoff

This study shows IRF4 deficiency leads to B cell leukemia via Jak3 mutations that increase IL-7 sensitivity, and JAK inhibition improves survival in a mouse model.

bioRxiv · Feb 16, 2022 · PreprintCancer Biology

In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets

M. Carlet, K. Voelse, J. Vergalli, M. Becker, T. Herold, A. Arner, W.-H. Liu, V. Dill, B. Fehse, C. D. Baldus, L. Bastian, L. Lenk, D. M. Schewe, J. W. Bagnoli, P. J. Jost, , I. Jeremias

The paper develops an in vivo inducible RNAi system in patient-derived xenograft models to identify therapeutic targets in acute leukemias.

bioRxiv · May 2, 2020Cancer Biology

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia

A. Rani James, M. P. Schroeder, M. Neumann, L. Bastian, C. Eckert, N. Gökbuget, J. O. Tanchez, C. Schlee, K. Isaakidis, S. Schwartz, T. Burmeister, A. v. Stackelberg, M. A. Rieger, S. Göllner, M. Horstman, , C. D. Baldus

This study identifies subtype and relapse-specific long non-coding RNAs in B cell precursor acute lymphoblastic leukemia and links them to molecular pathways and epigenetic regulation.

Journal of Hematology & Oncology · Jan 14, 2019Peer-reviewedCancer Biology