Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Deficiency Exacerbates Alcohol-Induced Hepatic Oxidative Stress, Inflammation, Steatosis, and Fibrosis
Y.-W. Lan, W.-R. Chen, C.-C. Yen, K.-Y. Chong, Y.-C. Chen, H.-C. Fan, M.-S. Chen, C.-M. Chen
This study shows that AKR1A1 deficiency worsens alcohol-induced liver damage by increasing oxidative stress, inflammation, steatosis, and fibrosis through 4-HNE/p53 signaling.
bioRxiv · Dec 7, 2022 · PreprintPathology