Proteome-wide computational analyses reveal links between protein condensate formation and RNA biology
Snigdha Maiti, Swarnendu Tripathi, David W. Baggett, Aaron H. Phillips, Cheon‐Gil Park, Jina Wang, Wahiduzzaman, W. Toler Freyaldenhoven, Swati Kinger, Brittany J. Pioso, John C. Bollinger, Ramiz Somjee, Benjamin Lang, M. Madan Babu, Richard W. Kriwacki
The paper develops a machine learning model to predict IDR condensation behavior, finding ~12% of human IDRs likely form condensates, enriched in RNA-related and membrane-less organelle functions.
Science Advances · Dec 3, 2025Peer-reviewedBioinformatics