Richard W. Kriwacki

Granular component sub-phases direct ribosome biogenesis in the nucleolus

The paper uses super-resolution microscopy to show that nucleolus granular component sub-phases are organized into multiphase condensates that facilitate ribosome subunit assembly.

A gated hydrophobic funnel within BAX binds long-chain alkenals to potentiate pro-apoptotic function

The paper identifies a hydrophobic funnel in BAX that binds 2t-hexadecenal, enhancing BAX activation with BIM, and shows proline 168 regulates this interaction.

Proteome-wide computational analyses reveal links between protein condensate formation and RNA biology

The paper develops a machine learning model to predict IDR condensation behavior, finding ~12% of human IDRs likely form condensates, enriched in RNA-related and membrane-less organelle functions.

Protein Dynamics at Different Timescales Unlock Access to Hidden Post-Translational Modification Sites

The paper investigates how protein conformational dynamics reveal hidden post-translational modification sites and their functional relevance across timescales.

MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia

This study identifies MOZ and HBO1 as molecular dependencies in NUP98-rearranged AML, showing their inhibition reduces leukemic burden and synergizes with Menin inhibitors.

Assembly of mTORC3 involves binding of ETV7 to two separate sequences in the mTOR kinase domain.

This study identifies mTORC3, a rapamycin-resistant mTOR complex that requires ETV7 binding, and shows that specific mTOR and ETV7 domains mediate this interaction, with implications for cancer therapy.