Swarnendu Tripathi

Granular component sub-phases direct ribosome biogenesis in the nucleolus

The paper uses super-resolution microscopy to show that nucleolus granular component sub-phases are organized into multiphase condensates that facilitate ribosome subunit assembly.

Proteome-wide computational analyses reveal links between protein condensate formation and RNA biology

The paper develops a machine learning model to predict IDR condensation behavior, finding ~12% of human IDRs likely form condensates, enriched in RNA-related and membrane-less organelle functions.

Assessing Protein Surface-Based Scoring for Interpreting Genomic Variants

This study introduces a method to score protein surface property changes for interpreting genomic variants, showing significant differences in charge distribution for known pathogenic variants.

Integration of Multi-level Molecular Scoring for the Interpretation of RAS-Family Genetic Variation

The paper develops and evaluates 3D structure-based scores for genomic variants and integrates them with sequence-based scores to better understand how variants affect protein function in the RAS gene family.