H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs
Brian Krug, Bo Hu, Haifeng Chen, Claudia Negrón-Lomas, Xiao Chen, Ahmed El Mouatani, Kristjan H. Gretarsson, Adam Ptack, Shriya Deshmukh, Nisha Kabir, Wajih Jawhar, Augusto Faria Andrade, Elias Joseph Jabbour, Ashot S. Harutyunyan, Xinrui Wang, , Chao Lü
The paper shows that H3K27me3 spreading regulates chromatin architecture and gene repression, with implications for cell fate and tumor development.
Nature Genetics · May 18, 2026Peer-reviewedMolecular Biology