Audrey Baguette

The paper shows that H3K27me3 spreading regulates chromatin architecture and gene repression, with implications for cell fate and tumor development.

The paper identifies SUZ12's nucleic acid-binding domain as critical for regulating PRC2 activity in H3 K27M gliomas, showing how it constrains enzymatic function and maintains targeted gene silencing.

Polaris is a tool for chromatin loop annotation in bulk and single-cell Hi-C data that outperforms existing methods across different datasets and conditions.

The paper investigates how gene orientation and position influence co-regulation domains (CODs) within topologically associating domains (TADs) using RNA-seq, ChIP-seq, and Hi-C data from A549 cells.