Benjamin Aaron Garcia

This study expands the HIF-2α proteomic interactome using TurboID proximity labeling, identifying 329 novel interactors and linking some to poor patient survival in breast cancer.

The paper shows that H3K27me3 spreading regulates chromatin architecture and gene repression, with implications for cell fate and tumor development.

This paper evaluates the potency and selectivity of MYST KAT inhibitors using chemoproteomic profiling and identifies new complex members, highlighting dose-dependent inhibition patterns and potential therapeutic applications.

The paper shows that cleavage of histone H2A by Cathepsin L during ESC differentiation reduces nucleosome stability and counteracts gene activation.

The paper identifies pseudouridine as a key modification enabling RNA extracellular transport and identifies MYL6 as a binding protein required for this process.

This study shows YY1 enhances p300 acetyltransferase activity in CRPC, promoting histone acetylation and oncogenic gene expression, and identifies a potential therapeutic target for overcoming drug resistance.

The paper identifies SUZ12's nucleic acid-binding domain as critical for regulating PRC2 activity in H3 K27M gliomas, showing how it constrains enzymatic function and maintains targeted gene silencing.

This study shows that inhibiting KAT6A/B with PF-9363 enhances retinoid efficacy and improves GD2-targeted immunotherapy in neuroblastoma.

This paper develops a top-down proteomics workflow to characterize and quantify calreticulin arginylation in vitro and in vivo.

The paper introduces RBR-scan, a method to identify RNA-binding mutants by measuring affinity of protein variants, and validates it with known and novel mutants in SRSF2.

This paper introduces an engineered sortase, cW11, for modifying and isolating histone H3 tails to study epigenetic modifications and their effects on enzyme processing and protein recognition.

The paper develops a robust LC-MS/MS workflow for quantifying H2AK119ub and H2BK120ub histone ubiquitination marks, improving upon existing methods for C-terminal modifications.

The paper systematically perturbs H3K36 methyltransferases in mouse mesenchymal stem cells to reveal their distinct roles in H3K36 methylation states and genomic distribution.

This study demonstrates that O-glycosylation contributes to sialoglycoRNA biogenesis and shows increased sialylation in ulcerative colitis-derived organoids.

This study shows acetate improves spatial memory in female mice via sex- and brain region-specific epigenetic and transcriptional changes in the dorsal hippocampus.

This study shows that ACL loss in the heart increases glucose oxidation and reduces citrate efflux, leading to metabolic remodeling and cardiac dysfunction.

This study shows ACSS2-mediated histone acetylation is critical for learning and memory in a mouse AD model, with acetate supplementation rescuing deficits.

The paper quantifies tissue-specific protein turnover rates in mouse fetuses using in utero isotopic amino acid injection and proteomic analysis.

This study shows that H4K91 mutants alter chromatin occupancy and misregulate neuronal differentiation, leading to microcephaly-like phenotypes in mice.

This study shows that inhibiting Acss2 reduces fear memory formation and anxiety in mice and rats by decreasing histone acetylation and gene expression in the hippocampus.

The paper examines the role of epigenetics in the transition from unicellular to multicellular states in Dictyostelium discoideum, identifying conserved genes and validating their necessity or sufficiency for multicellularity.

The paper introduces a method to quantify lysine and arginine PTMs in NASH using mass spectrometry and applies it to mouse liver lysates, finding altered methylation and acetylation in NASH.

This study examines sex-specific metabolic and transcriptomic effects of IVF in mice, finding sex-dimorphic dysregulation of SREBP pathways and placental DNA methylation changes linked to cholesterol levels.

The paper profiles Y1 cells treated with FGF-2, revealing epigenetic and transcriptomic changes consistent with oncogene-induced senescence.

The paper demonstrates a two-step mechanism of PRC2-mediated repressive domain formation through nucleation sites and long-range spreading of H3K27me2/3.

This study identifies epididymal glucocorticoid receptors as mediators of paternal stress effects on offspring through changes in extracellular vesicle miRs.