Xiao Chen

The paper introduces CombiDOCK and MINT-Dock to efficiently screen large molecule libraries for ligand discovery, achieving high hit rates and computational efficiency.

The paper shows that H3K27me3 spreading regulates chromatin architecture and gene repression, with implications for cell fate and tumor development.

This study provides the first multi-omics analysis of encystment in Oxytricha granulifera, revealing mechanisms of dormancy through genomic, transcriptomic, and proteomic data.

The paper identifies SMARCAL1 as a key regulator of ALT metabolism and a potential therapeutic target for ALT-positive tumors.

This study introduces SomaGauss-SV, a nanopore-based method for detecting somatic structural variations in LSCC, revealing correlations with smoking and gene expression.

The paper identifies sgACC functional connectivity abnormalities in depression using large-scale brain imaging data and develops an individualized TMS targeting algorithm to improve treatment outcomes.

This study improves gene annotation in Tetrahymena thermophila by integrating transcriptomic and epigenetic data, adding new genes and UTRs while identifying antisense transcripts.

The paper identifies small cytosolic DNAs (scDNAs) that inhibit cGAS activation and induce autophagy, preventing excessive inflammation.

This study investigates the epigenetic and transcriptomic effects of NSD1 mutations in head and neck squamous cell carcinoma, showing loss of H3K36me2 and DNA methylation, and gain of H3K27me3, leading to gene expression changes.

This study analyzes the genome and transcriptome of Euplotes vannus to uncover molecular mechanisms of sex determination and stress tolerance.

The paper compares nucleosome distribution patterns between two nuclei in Tetrahymena thermophila, finding distinct positioning in the active MAC and delocalized patterns in the silent MIC.