Reduced cortico-accumbal excitatory input due to Nav1.2 haploinsufficiency impairs sociability independently of dopamine
Toshimitsu Suzuki, Shiori Tominaga, Yuto Yokoi, Hiroaki Mizukami, Kenta Kobayashi, Wakana Nishida, Kona Yamashita, Takahiko Kondo, Yurina Hibi, Tetsushi Yamagata, Shigeyoshi Itohara, Hiroshi Nomura, Hideki Hida, Kazuhiro Yamakawa
This study shows that reduced excitatory input to the nucleus accumbens due to Scn2a haploinsufficiency impairs sociability without affecting dopamine levels.
bioRxiv · Apr 16, 2026 · PreprintNeuroscience