Shigeyoshi Itohara

Reduced cortico-accumbal excitatory input due to Nav1.2 haploinsufficiency impairs sociability independently of dopamine

This study shows that reduced excitatory input to the nucleus accumbens due to Scn2a haploinsufficiency impairs sociability without affecting dopamine levels.

Differential Effects of Inducible Cerebellar Granule Cell and Purkinje Cell Ablation on Motor Coordination and Motor Learning in Adult Mice

This study compares the effects of selective cerebellar granule cell and Purkinje cell ablation on motor coordination and learning in adult mice, finding that GCs are more critical for motor learning.

Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons

The paper confirms mutually exclusive Nav1.1 and Nav1.2 expression in neocortical neurons and identifies Nav1.1 expression in specific excitatory subpopulations.

Cross-Species BAC Transgenesis Reveals Long-Range Regulation Drives Variation in Brain Oxytocin Receptor Expression and Social Behaviors

The paper generates transgenic mice with prairie vole Oxtr locus to study how long-range genomic regulation affects brain OXT receptor expression and social behaviors.

A role for axon-glial interactions and Netrin-G1 signaling in the formation of low-threshold mechanoreceptor end organs

Distributed sensory coding by cerebellar complex spikes in units of cortical segments

The paper investigates how sensory signals are represented in the cerebellum by analyzing complex spikes in mouse brain segments.

A spike-sorting method based on hierarchical clustering to discriminate extracellularly recorded simple spikes and complex spikes from cerebellar Purkinje cells

The paper introduces a spike-sorting method using hierarchical clustering to distinguish complex and simple spikes from Purkinje cells, achieving 96.6% detection accuracy using in vivo Ca2+ imaging validation.

Transient astrocytic Gq signaling underlies remote memory enhancement

This study shows that transient astrocytic Gq signaling enhances remote memory through adenosine A1 receptor-dependent mechanisms.

Limb-clasping, cognitive deficit and increased vulnerability to kainic acid -induced seizures in neuronal GPI anchor deficiency mouse models

This study generates PIGA-deficient mouse models to investigate the role of GPI anchor deficiency in neurological phenotypes and seizure susceptibility.

The hippocampus encodes delay and value information during delay-discounting decision making

This study identifies hippocampal neuron subpopulations that encode delay and value information during delay-discounting decisions in mice.

Behavior variability of a conditional gene knockout mouse as a measure of subtle phenotypic trait expression. The case of mouse brain executive function distortion

The paper shows that conditional Ntng1 knockout in specific brain circuits affects mouse executive function traits like impulsivity and attention, but not overall EF, while complete knockout leads to EF deficits.

MOLECULAR CORRELATE OF MOUSE EXECUTIVE FUNCTION. TOP-DOWN AND BOTTOM-UP COMPLEMENTATIONS BY PRESYNAPTIC VERTEBRATE BRAIN-SPECIFIC Ntng GENE PARALOGS

The paper investigates the role of Ntng gene paralogs in mouse executive function, showing differential expression in brain regions and task-dependent modulation of cognitive processes.

COGNITIVE DOMAINS FUNCTION COMPLEMENTATION BY NTNG GENE PARALOGS

The paper investigates how NTNG1 and NTNG2 paralogs functionally complement each other in cognitive domains and contribute to neurocognitive disorders through subfunctionalization.

COGNITIVE ENDOPHENOTYPES OF MODERN AND EXTINCT HOMININS ASSOCIATED WITH NTNG GENE PARALOGS

The paper identifies cognitive endophenotypes linked to NTNG gene paralogs in humans and extinct hominins, showing evolutionary changes and associations with IQ traits.