Kenta Kobayashi

The paper shows that prior auditory learning inhibits somatosensory responses in mice through ACC-S1 projections, promoting blocking of redundant associations.

This study uses CRISPR-ON to increase Stxbp1 expression in a mouse model, restoring Munc18-1 protein levels but not fully reversing disease symptoms.

This study shows that reduced excitatory input to the nucleus accumbens due to Scn2a haploinsufficiency impairs sociability without affecting dopamine levels.

The paper identifies nucleus accumbens parvalbumin-expressing fast-spiking inhibitory neurons as critical for convulsive seizure generation in mice with STXBP1 or SCN2A mutations.

The paper investigates network structure changes during sleep and anesthesia at single-cell and mesoscales, finding increased modularity at the single-cell level and spatially intermixed modules across states.

This study maps the anatomical and neurochemical profiles of GABAergic projection neurons in the mouse inferior colliculus, revealing their specific targets and roles in auditory processing.

This study identifies the thalamo-insular pathway as critical for tic generation in a mouse model of Tourette syndrome, showing that its inhibition reduces tic-like behaviors.

The paper shows pregnancy in mice reduces excitatory inputs to PVH oxytocin neurons, promoting increased food intake by dampening their anorexigenic activity.

This study shows that the orbitofrontal cortex promotes alloparental caregiving in female mice by modulating dopamine dynamics during behavior acquisition.

APEX-Ribo-Seq maps local translation across organelles and identifies compartment-specific transcripts, revealing sequence features and dynamics of subcellular translation.

This study shows that GABA signaling in the optic nerve mediates experience-dependent myelination, with binocular deprivation having less impact than monocular deprivation.

This study shows that the interhemispheric pathway's role in motor recovery changes from inhibitory to facilitatory in primates after corticospinal tract lesioning, affecting hand movements during early recovery.

This study shows that SCN neurons maintain circadian rhythms at moderate hypothermia but suspend them at deep hypothermia, with Ca2+ rhythms resetting faster than transcriptional rhythms upon rewarming.

This study investigates how motor direction representation changes in primate premotor and primary motor cortices during learning, finding that PMdc neurons dynamically adjust their preferred direction while M1 neurons maintain stability.

The paper demonstrates that optogenetic actuators in starburst amacrine cells enhance visual restoration in murine retinas through gap junctions.

This study shows that global disinhibition and corticospinal plasticity enable drastic motor recovery after spinal cord injury in macaques through intensive training and cortical electrical stimulation.

The paper investigates leaky expression of 3' transgenes in bicistronic vectors and shows that 5' transgenes can drive promoter-like activity, leading to Cre-independent expression.

This paper introduces a low computational-cost cell detection method for calcium imaging data, showing it is faster and equally accurate compared to existing methods.

This paper introduces a non-invasive in vivo imaging system to monitor neural graft activity after spinal cord injury and shows graft integration with host behavior.

This study uses chemogenetic suppression of the subthalamic nucleus in monkeys to show it reduces spike variability in the basal ganglia, leading to more stable movements.

The paper demonstrates that ectopic expression of chimeric rhodopsin in mice restores dim-light vision and prevents retinal degeneration.

The paper introduces FASHIO-2PM, a two-photon microscope that enables fast, aberration-free calcium imaging of large neural networks in awake mice at 7.5 Hz.

This study demonstrates effective optogenetic stimulation of the macaque motor cortex to evoke forelimb movements and muscle activity comparable to conventional electrical stimulation.

This study shows that motor cortex directly connects to globus pallidal neurons in rats, with differential projections based on cortical area and neuron type.

The paper investigates context-dependent differences in orienting and defense-like responses mediated by distinct pathways in the superior colliculus using optogenetic activation in mice.

This study identifies a ventral hippocampal pathway that gates novelty-driven memory formation by activating dorsal hippocampal granule cells.

The paper identifies a novel GABAergic neuron population in the olfactory cortex of mice that project to the lateral hypothalamus and integrate olfactory and top-down inputs.

This study shows that D1 and D2 neurons in the anteromedial olfactory tubercle of mice have opposing roles in mediating attractive and aversive behaviors during place preference tests.

The paper re-evaluates Ca2+ release from the ER in IP3R2-KO astrocytes using imaging and finds attenuated but significant ER Ca2+ release independent of IP3R2.

This paper demonstrates two-photon calcium imaging up to 1200 m below the cortical surface in mice, revealing higher reward prediction activity in the prelimbic area compared to the hippocampal CA1 region.