Author

Tetsushi Yamagata

Nagoya City UniversityORCID 0000-0002-5734-7932Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 6

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Kazuhiro YamakawaiD· 6 shared Toshimitsu SuzukiiD· 6 shared Yurina Hibi· 5 shared Hiroaki MizukamiiD· 3 shared Kenta KobayashiiD· 3 shared Shigeyoshi ItoharaiD· 2 shared Takahiko Kondo· 2 shared Emi Mazaki· 1 shared

Activity by Year

2023-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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6 shared papersNeuroscience

Kazuhiro YamakawaORCID

Mutual co-authors in cluster

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6 papers

Recent·Most cited

CRISPR-mediated Stxbp1 gene activation restores Munc18-1 levels in Stxbp1-haploinsufficient mice

Tetsushi Yamagata, Ryu Ikebe, Kenta Kobayashi, Masanari Saito, Yurina Hibi, Kazuhiro Yamakawa, Toshimitsu Suzuki

This study uses CRISPR-ON to increase Stxbp1 expression in a mouse model, restoring Munc18-1 protein levels but not fully reversing disease symptoms.

bioRxiv · Jun 9, 2026 · PreprintNeuroscience

Reduction of Nav1.1 in the dorsal striatum preferentially increases hyperthermia-induced generalized seizures compared with the neocortex and nucleus accumbens

Tetsushi Yamagata, Hiroaki Mizukami, Yurina Hibi, Kazuhiro Yamakawa, Toshimitsu Suzuki

This study shows that reducing Nav1.1 in the dorsal striatum increases hyperthermia-induced seizures more than in the neocortex or nucleus accumbens.

bioRxiv · May 14, 2026 · PreprintNeuroscience

Reduced cortico-accumbal excitatory input due to Nav1.2 haploinsufficiency impairs sociability independently of dopamine

Toshimitsu Suzuki, Shiori Tominaga, Yuto Yokoi, Hiroaki Mizukami, Kenta Kobayashi, Wakana Nishida, Kona Yamashita, Takahiko Kondo, Yurina Hibi, Tetsushi Yamagata, Shigeyoshi Itohara, Hiroshi Nomura, Hideki Hida, Kazuhiro Yamakawa

This study shows that reduced excitatory input to the nucleus accumbens due to Scn2a haploinsufficiency impairs sociability without affecting dopamine levels.

bioRxiv · Apr 16, 2026 · PreprintNeuroscience

Parallel analysis of voltage-gated sodium channel subunits reveals preferential colocalizations of beta-1/Nav1.1 and beta-2/Nav1.2

Tetsushi Yamagata, Toshimitsu Suzuki, Kazuhiro Yamakawa

The paper examines the co-expression patterns of voltage-gated sodium channel subunits in neurons across different brain regions and developmental stages, revealing distinct subunit combinations in inhibitory and excitatory neurons.

bioRxiv · Mar 16, 2026 · PreprintNeuroscience

Reduced activity of nucleus accumbens parvalbumin-expressing fast- spiking inhibitory neurons causes convulsive seizures

Toshimitsu Suzuki, Takahiko Kondo, Tetsushi Yamagata, Yurina Hibi, Hiroaki Mizukami, Kenta Kobayashi, Kazuhiro Yamakawa

The paper identifies nucleus accumbens parvalbumin-expressing fast-spiking inhibitory neurons as critical for convulsive seizure generation in mice with STXBP1 or SCN2A mutations.

bioRxiv · Mar 10, 2026 · PreprintNeuroscience

Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons

Tetsushi Yamagata, Ikuo Ogiwara, Tetsuya Tatsukawa, Toshimitsu Suzuki, Yuka Otsuka, Nao Imaeda, Emi Mazaki, Ikuyo Inoue, Natsuko Tokonami, Yurina Hibi, Shigeyoshi Itohara, Kazuhiro Yamakawa

The paper confirms mutually exclusive Nav1.1 and Nav1.2 expression in neocortical neurons and identifies Nav1.1 expression in specific excitatory subpopulations.

eLife · May 10, 2023Peer-reviewedNeuroscience