Endocannabinoid signaling is a critical link between circadian desynchronization and metabolic dysfunction
Brennan A. Baca, Giancarlo Denaroso, Saïd Akli, Gregory Pearson, Jiexin Wang, Nicole P. Bowles, Derrick J. Phillips, Walker Sorensen, Catherine Hume, Matthew N. Hill, Ilia N. Karatsoreos
This study shows that endocannabinoid signaling via CB1r mediates metabolic dysfunction caused by circadian desynchronization, with the liver playing a key role.
bioRxiv · Sep 29, 2025 · PreprintPhysiology