Universal activation mechanism of class A GPCRs
Qingtong Zhou, Dehua Yang, Meng Wu, Yu Guo, Wangjing Guo, Zhong Li, Xiaoqing Cai, Antao Dai, Eugene I. Shakhnovich, Zhi‐Jie Liu, Raymond C. Stevens, M. Madan Babu, Ming‐Wei Wang, Suwen Zhao
The paper identifies a universal activation mechanism for class A GPCRs by analyzing high-resolution structures, linking ligand binding to G protein coupling through TM6 movement.
bioRxiv · Jul 22, 2019 · PreprintBioinformatics