Ming‐Wei Wang

Molecular mechanisms of uric acid transport by the native human URAT1 and its inhibition by anti-gout drugs

This study presents cryo-EM structures of hURAT1 bound with anti-gout drugs and uric acid, revealing transport mechanisms and drug inhibition.

Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9-36) in conjunction with LSN3318839

This study reveals the molecular mechanism by which GLP-1(9-36) and the allosteric modulator LSN3318839 enhance GLP-1R signaling through distinct structural interactions.

A unique peptide recognition mechanism by the human relaxin family peptide receptor 4 (RXFP4)

The paper reports cryo-EM structures of RXFP4-Gi complexes with INSL5 and agonists, revealing a unique peptide-binding mechanism and subtype selectivity determinants.

Structural basis of peptidomimetic agonism revealed by small molecule GLP-1R agonists Boc5 and WB4-24

This paper reports cryo-EM structures of small molecule GLP-1R agonists Boc5 and WB4-24, revealing a novel binding pocket and mechanism for peptidomimetic agonism.

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

This study reports the cryo-EM structure of the human VIP2R bound to PACAP27 and Gs, revealing a unique N-terminal helix conformation that stabilizes the ligand-receptor interface.

Ligand-independent modulation of GIPR signaling by splice variants

The paper investigates how splice variants of GIPR modulate cAMP and β-arrestin signaling independently of ligand binding.

Constitutive signal bias mediated by the human GHRHR splice variant 1

The paper identifies a splice variant of the GHRHR receptor that mediates constitutive signal bias towards β-arrestin recruitment, impacting downstream signaling pathways in prostate cancer cells.

Structural insights into ligand recognition and activation of the melanocortin-4 receptor

The paper reports high-resolution structures of MC4R with agonists and reveals insights into ligand recognition and activation mechanisms.

Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors

This study determines cryo-EM structures of dual and triple agonists bound to GIPR, GLP-1R, and GCGR to elucidate their superior efficacy over monoagonists in glucose homeostasis.

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

The paper reports the cryo-EM structure of the human GIPR complexed with GIP and a Gs heterotrimer, revealing how GIP is recognized and activates the receptor.

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

The paper reports cryo-EM structures of GLP-1R with ago-allosteric modulators, revealing their mechanism of action and providing insights for therapeutic design.

Universal activation mechanism of class A GPCRs

The paper identifies a universal activation mechanism for class A GPCRs by analyzing high-resolution structures, linking ligand binding to G protein coupling through TM6 movement.