Zhi‐Jie Liu

This paper introduces a method to analyze cryo-EM data as continuous structural landscapes, revealing molecular dynamics and previously unresolved states.

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

The paper uses super-resolution fluorescence imaging to reveal periodic CB1 receptor clusters in neurons and their interaction with the MPS.

The paper identifies a universal activation mechanism for class A GPCRs by analyzing high-resolution structures, linking ligand binding to G protein coupling through TM6 movement.