Raymond C. Stevens

The 4th GPCR Dock: assessment of blind predictions for GPCR-ligand complexes in the era of AlphaFold

This paper assesses GPCR-ligand complex predictions in the era of AlphaFold, showing AI models can match or exceed low-resolution experimental structures but still need high-resolution data and hybrid methods.

Ligand-independent modulation of GIPR signaling by splice variants

The paper investigates how splice variants of GIPR modulate cAMP and β-arrestin signaling independently of ligand binding.

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

The paper reports the cryo-EM structure of the human GIPR complexed with GIP and a Gs heterotrimer, revealing how GIP is recognized and activates the receptor.

Assessment of scoring functions to rank the quality of 3D subtomogram clusters from cryo-electron tomography

This study evaluates 15 scoring functions to rank the quality of 3D subtomogram clusters from cryo-electron tomography, identifying two robust methods that work across varying signal-to-noise ratios.

Universal activation mechanism of class A GPCRs

The paper identifies a universal activation mechanism for class A GPCRs by analyzing high-resolution structures, linking ligand binding to G protein coupling through TM6 movement.