Clofazimine targets essential nucleoid associated protein, mycobacterial integration host factor (mIHF), in Mycobacterium tuberculosis
Wanliang Shi, Shuo Zhang, Jie Feng, Peng Cui, Wenhong Zhang, Ying Zhang
This study identifies mIHF as the target of clofazimine in Mycobacterium tuberculosis, showing it inhibits DNA binding and gene expression, offering new insights into its mechanism of action.
bioRxiv · Sep 21, 2017 · PreprintMicrobiology