Author

Shuo Zhang

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Neuroscience· 2 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

Adam G. ChatoffiD· 1 shared Ahnaf Tausif· 1 shared Alison JaccardiD· 1 shared Andrea Andress HuacachinoiD· 1 shared Baizhou LiiD· 1 shared Belinda M. GiardineiD· 1 shared Bo-Xin Zhang· 1 shared Brian C. CapelliD· 1 shared

Activity by Year

2017-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperImmunology

Adam G. ChatoffORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Nutrient-sensitive histone propionylation regulates T cell fate and function

Alison Jaccard, Kelly Rome, Qihua Yang, Shuo Zhang, Noah Ford, Adam G. Chatoff, Tran Ngoc Van Le, Michael Noji, Andrea Andress Huacachino, Stephanie Stransky, Carlos M. Pondevida, Krittin Trihemasava, Laura V. Pinheiro, Sanat Bhadsalve, Eun Kyung Ko, , Kathryn E. Wellen

This study shows that histone propionylation, influenced by nutrient availability, regulates T cell fate and antitumor immunity.

bioRxiv · Oct 6, 2026 · PreprintImmunology

LDB1-dependent enhancer connectivity defines T-cell leukemia identities and masks metabolic vulnerabilities

Rahul S. Bhansali, Juan Sebastian Long, Petri Pölönen, Tomoya Isobe, Siqing Wang, Shuo Zhang, Zhuangzhuang Geng, Ahnaf Tausif, Mariah C. Antopia, Nicholas G. Aboreden, Sarah J. Skuli, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, Kai Tan, , Gerd A. Blobel

The paper identifies LDB1-dependent enhancer connectivity as critical for T-cell leukemia subtypes and reveals a metabolic vulnerability exploitable by statins.

bioRxiv · Jun 30, 2026 · PreprintCancer Biology

Z-RNA-ZBP1 axis drives Tau-mediated neurodegeneration

Wei Liu, Song-Ang Wu, Bo-Xin Zhang, Shaoyu Guo, Lang Li, Wenjing Sun, Xushen Xiong, Jiuhong Nan, Jianfeng Wu, Linghui Zeng, Pilong Li, Zhiyu Cai, Huan-Feng Ye, Shuo Zhang, Sheng Nie, , Wei Mo

The paper identifies the Z-RNA-ZBP1 axis as a driver of Tau-mediated neurodegeneration and shows that ZBP1 inhibition can alleviate cognitive deficits in Tau-transgenic mice.

bioRxiv · Feb 17, 2026 · PreprintNeuroscience

ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration

Naemeh Pourshafie, Desi C. Alexander, Hong Wei Xu, Kechun Yang, Greg Donahue, Xue Lei, Shuo Zhang, Oksana Shcherbakova, Connor Hogan, Michael Gilbert, Kevt’her Hoxha, Lesley S. Chaboub, Virginia M.‐Y. Lee, Peter D. Adams, John A. Dani, , Shelley L. Berger

This study shows that increasing ACSS2 levels protects neurons from age-related and tau-induced decline by enhancing synaptic and longevity gene expression.

Proceedings of the National Academy of Sciences · Jan 9, 2026Peer-reviewedNeuroscience

Clofazimine targets essential nucleoid associated protein, mycobacterial integration host factor (mIHF), in Mycobacterium tuberculosis

Wanliang Shi, Shuo Zhang, Jie Feng, Peng Cui, Wenhong Zhang, Ying Zhang

This study identifies mIHF as the target of clofazimine in Mycobacterium tuberculosis, showing it inhibits DNA binding and gene expression, offering new insights into its mechanism of action.

bioRxiv · Sep 21, 2017 · PreprintMicrobiology