CRISPR/Cas9-mediated identification of human macrophage SphK1 as druggable target for development of anti-leishmanial chemotherapeutics
Evanka Madan, Jhalak Singhal, Aashima Gupta, Soumyadeep Mukherjee, Waseem Dar, Neha Jha, Pragya Gupta, Soumya Pati, Sivaprakash Ramalingam, Shailja Singh
This study identifies SphK1 as a druggable target in human macrophages for anti-leishmanial therapy by showing its role in promoting Leishmania donovani survival through immune evasion and cell fate regulation.
bioRxiv · Aug 18, 2025 · PreprintMolecular Biology