Genetically encoded assembly recorder temporally resolves cellular histories in cellulo and in vivo
Yuqing Yan, Jiaxi Lu, Zhe Li, Zuohan Zhao, Timothy F. Shay, Shunzhi Wang, Yaping Lei, Yimei Wang, Wei Chen (23863), Patrick Parker, Hongru Yang, Aileen Qi, Yongzhi Sun, Dwight E. Bergles, David A. Baker, Dingchang Lin
This paper introduces GEMINI, a tool that records cellular activity histories with high temporal resolution, and demonstrates its application in tracking transcriptional changes and inflammation dynamics in vivo.
Nature · Mar 3, 2026Peer-reviewedBioengineering