Dwight E. Bergles

Microglia extract neuronal proteolytic organelles via skoupocytosis

The paper shows microglia extract proteolytic organelles from neurons via a process called skoupocytosis, which bypasses retrograde transport and aids neuronal homeostasis.

Tonotopically distinct OFF responses arise in the mouse auditory midbrain following sideband suppression

This study shows that hearing loss alters spatiotemporal neural activity patterns in the mouse auditory midbrain, specifically abolishing sideband suppression and tdOFF responses, which may contribute to tinnitus and hyperacusis.

Mutant SOD1 expressed by oligodendrocytes aggregates in myelinic nanochannels and accelerates disease progression in familial ALS mice

This study shows that mutant SOD1 aggregates in myelinic nanochannels and accelerates ALS progression in mice, highlighting the role of myelin channel integrity in disease.

Conservation of neuron-astrocyte coordinated activity among sensory processing centers of the developing brain

The paper shows that retinal ganglion cell activity induces correlated astrocyte calcium waves in the superior colliculus, dependent on mGluR5 and mGluR3, suggesting a conserved mechanism across sensory systems.

Genetically encoded assembly recorder temporally resolves cellular histories in cellulo and in vivo

This paper introduces GEMINI, a tool that records cellular activity histories with high temporal resolution, and demonstrates its application in tracking transcriptional changes and inflammation dynamics in vivo.

Astrocyte-induced internal state transitions reshape brainwide sensory, integrative, and motor computations

The paper shows that astrocyte activity drives brainwide changes in sensory, integrative, and motor computations during a passive state in zebrafish.

Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and affective behavior in epilepsy

This study shows that astrocyte redox imbalance causes neuronal hypoactivity and affective behaviors in epilepsy, distinct from seizure mechanisms.

Versatile high-speed volumetric imaging from microscopic to macroscopic scale by self-adaptive oblique plane microscopy

This paper introduces a self-adaptive oblique plane microscopy technique that enables high-speed volumetric imaging across microscopic to macroscopic scales in multi-cellular systems.

Spontaneous calcium transients in hair cell stereocilia

This study detects spontaneous calcium transients in hair cell stereocilia using fluorescent sensors and microscopy, showing they originate from mechanoelectrical transduction channels and occur in multiple stereocilia regions.

Altered development and network connectivity in a human neuronal model of 15q11.2 deletion-related neurodevelopmental disorders

This study examines 15q11.2 deletion effects on neuronal development and function using iPSC-derived neurons, finding structural and functional impairments in network connectivity and maturation.

Transcriptional profiles of murine oligodendrocyte precursor cells across the lifespan

This study investigates how aging affects oligodendrocyte precursor cells (OPCs) by analyzing their transcriptional profiles across the lifespan using single-cell RNA sequencing.

Calcium-permeable AMPA receptors govern PV neuron feature selectivity

This study shows that calcium-permeable AMPA receptors (CP-AMPARs) in PV interneurons reduce their feature selectivity, and removing them increases selectivity in visual cortex and hippocampus.

Brain-wide mapping of oligodendrocyte organization and oligodendrogenesis across the murine lifespan

The paper maps oligodendrocyte organization and dynamics across the mouse lifespan, revealing age- and region-specific differences in oligodendrogenesis and resilience.

Potassium regulates axon-oligodendrocyte signaling and metabolic coupling in white matter

This study shows that oligodendrocytes use potassium signaling to regulate axonal metabolism and maintain axonal health through metabolic coupling.

Multicore fiber optic imaging reveals that astrocyte calcium activity in the cerebral cortex is modulated by internal motivational state

This study uses a multi-core fiber optic imaging platform to show that astrocyte calcium activity in the cerebral cortex varies with internal motivational states and neuromodulatory systems.

Cross-modality supervised image restoration enables nanoscale tracking of synaptic plasticity in living mice

The paper develops a deep learning image restoration method to enhance in vivo synaptic imaging resolution using ex vivo super-resolution techniques, enabling tracking of synaptic plasticity in living mice.

MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity

The paper shows ketamine suppresses futility-induced passivity in zebrafish by modulating astroglial calcium through norepinephrine signaling.

Preservation of prehearing spontaneous activityenables early auditory system development in deaf mice

The paper shows that in deaf mice lacking connexin 26, cochlear supporting cells retain spontaneous activity, preserving early auditory circuit development despite structural cochlear changes.

Cell-specific regulation of gene expression using splicing-dependent frameshifting.

This paper introduces SLED, a splicing-based method to control gene expression in specific cell types, demonstrating its utility in targeting neurons, photoreceptors, and cancer cells.

Norepinephrine enhances oligodendrocyte precursor cell calcium dynamics in the cerebral cortex during arousal

This study shows norepinephrine modulates OPC calcium dynamics and lineage progression in vivo through adrenergic signaling.

Developmental spontaneous activity promotes sensory domains, frequency tuning and proper gain in central auditory circuits

This study shows that cochlear spontaneous activity during development is crucial for proper auditory circuit maturation, affecting frequency tuning and neural gain.

Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43

This study shows that TDP-43 loss affects oligodendrocyte survival and myelination differently at various stages of maturation, leading to morphological defects and neurological impairments.

Oligodendrocytes form paranodal bridges that generate chains of myelin sheaths vulnerable to degeneration with age

The paper identifies a conserved myelination mechanism in oligodendrocytes that forms paranodal bridges, enabling extended myelin sheaths along axons, which degenerate more frequently with age.

Oligodendrocyte precursor cells prune axons in the mouse neocortex

The paper identifies oligodendrocyte precursor cells (OPCs) as major contributors to axon pruning in the mouse neocortex through phagocytic activity.

Automated in vivo tracking of cortical oligodendrocytes

This paper introduces an automated cell tracking pipeline, Oligo-Track, to analyze oligodendrocyte dynamics in vivo, revealing suppressed oligodendrogenesis in deeper cortical layers after demyelination.

Remyelination restores myelin content on distinct neuronal subtypes in the cerebral cortex

This study shows that remyelination restores myelin content on distinct neuronal subtypes in the cerebral cortex, preserving relative differences in myelin content despite changes in distribution.

Purinergic signaling controls spontaneous activityin the auditory system throughout early development

The paper shows that purinergic signaling via ATP release from inner supporting cells drives spontaneous activity in the auditory system from birth to hearing onset, promoting coordinated neural firing in frequency-specific circuits.

Remyelination alters the pattern of myelin in the cerebral cortex

This study uses in vivo imaging to show that remyelination after oligodendrocyte ablation in mice leads to altered myelin patterns in the cerebral cortex, with impaired regeneration in deeper layers.

Persistent Cyfip1 expression is required to maintain the adult subventricular zone neurogenic niche

This study shows that Cyfip1 is critical for maintaining the adult subventricular zone niche by regulating B1 cell proliferation and adherens junction proteins.