Proteome profiling reveals HES1-driven mitotic catastrophe in ovarian serous carcinoma
Jie Bao, Sanna Pikkusaari, Jun Dai, Samuel Leppiniemi, Wenjun Huang, Weiming Yang, Anu Anil, Mirva Pääkkönen, Chuqi Lei, Eva Daniela Mendoza Ortiz, Ezgi Karagöz, Johanna Eriksson, Min Li, Johanna Hynninen, Otto Kauko, , Jing Ping Tang
This study identifies BX-912 as a therapeutic agent for ovarian serous carcinoma, revealing HES1 as a target and showing synergistic effects with olaparib.
bioRxiv · Aug 20, 2025 · PreprintCancer Biology