Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, , Chencheng Yao
This paper develops a spermatocytes-tropic mRNA-LNP delivery system to treat genetic spermatogenic disorders, showing restoration of spermatogenesis in mouse models.
Advanced Science · Feb 11, 2026Peer-reviewedMolecular Biology