Wenbo Li

Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells

The paper identifies pre-established chromatin regions in human ESCs that enable rapid activation of lineage-specific genes during differentiation.

Developing a general AI model for integrating diverse genomic modalities and comprehensive genomic knowledge

The paper develops a general AI model that integrates diverse genomic modalities and knowledge, showing strong performance across cell types and tissues.

Generation of Region-specific Airway Basal Stem Cells from Human Pluripotent Stem Cells via Regulation of NOGGIN-BMP Axis

This study generates region-specific airway basal stem cells from human pluripotent stem cells by modulating the NOGGIN-BMP axis, showing distinct differentiation potentials for proximal and distal airway cell types.

Non-mutated human tau stimulates Alzheimer's disease-relevant neurodegeneration in a microglia-dependent manner

This study shows that non-mutated human tau causes neurodegeneration in a microglia-dependent manner in a mouse model of Alzheimer's disease.

A Thiopurine-like Mutagenic Process Defines TGCT Subtypes

This study identifies a unique mutational signature, SBS87, in testicular germ cell tumors (TGCTs) that resembles thiopurine-induced DNA damage and is associated with tumor latency and telomere elongation.

Rewired m6A methylation of promoter antisense RNAs in Alzheimer disease regulates global gene transcription in the 3D nucleome

The paper identifies AD-associated changes in m6A methylation on promoter antisense RNAs and shows their role in regulating gene expression and neuronal survival in Alzheimer's disease.

Recruitment of CTCF to the SIRT1 promoter after Oxidative Stress mediates Cardioprotective Transcription

The paper shows that phosphorylated CTCF binds the SIRT1 promoter under oxidative stress, activating a cardioprotective transcriptional program in cardiomyocytes.

Genome-wide analysis of the interplay between chromatin-associated RNA and 3D genome organization in human cells

This study investigates how chromatin-associated RNA interacts with 3D genome organization in human cells, revealing a feedback loop between RNA distribution and chromatin structure.

SARS-CoV-2 Restructures the Host Chromatin Architecture

This study investigates how SARS-CoV-2 alters host chromatin architecture and epigenome, revealing disruptions in 3D genome structure and transcriptional regulation of immune-related genes.

Three-dimensional genome reorganization during mouse spermatogenesis

This study investigates 3D genome reorganization during mouse spermatogenesis, revealing dynamic changes in TADs, chromatin loops, and transcriptional regulation.