Histone deacetylase inhibition expands cellular proteostasis repertoires to enhance neuronal stress resilience
Caitlin Ann Taylor, Maya Maor-Nof, Wendy A. Herbst, Shihong Max Gao, Xinyue Li, Eyal Metzl-Raz, Aaron Hidalgo, Faria Zafar, Callista Stephanie Yee, Birgitt Schüle, Meng Carla Wang, Aaron D. Gitler, Kang Shen
This study shows that inhibiting histone deacetylases enhances neuronal resilience to stress by inducing a permissive transcriptional state and activating proteostasis pathways.
bioRxiv · Aug 21, 2024 · PreprintNeuroscience