Shihong Max Gao

This paper reveals that dopamine release is highly localized to synapse-like structures, challenging the idea that neuromodulators act diffusely.

This paper introduces sOrganellomics, a method to map cell state diversity and metabolic adaptation in tissues using spatial imaging and machine learning, revealing new insights into hepatocyte organization and metabolic changes under stress.

This study investigates how actin structure and function affect aging in C. elegans and finds that actin dysfunction accelerates aging hallmarks and correlates with human age-related decline in gait speed.

The paper shows that midgestational metabolic constraints in purine metabolism drive distinct strategies for placenta and fetal growth in mice and humans.

This paper uses ex utero culture to study mouse embryogenesis from gastrulation to fetal development, revealing metabolically independent programs and environmental influences on metabolic transitions.

This study identifies SLC29A homologs in C. elegans that mediate nucleoside coordination between soma and germline, revealing guanosine as critical for reproduction.

This study shows that inhibiting histone deacetylases enhances neuronal resilience to stress by inducing a permissive transcriptional state and activating proteostasis pathways.

This study generates single-cell transcriptomic atlases of C. elegans across its lifespan under pro-longevity conditions to identify cell-type-specific aging mechanisms and regulatory changes.