Kang Shen

This study shows that the dendritic guidance receptor DMA-1 functions both ligand-dependently and -independently, promoting stochastic outgrowth and stabilizing stereotyped dendritic morphology.

This study identifies ERM proteins as regulators of EPJ shape and number in neurons through actin bundling and phase separation.

SuRe enables efficient integration of multiple transgenes at a single genomic locus by using CRISPR/Cas9 and serine recombinases, allowing up to 4.2 Mbp recombinant products in Drosophila.

This study shows UNC-33 maintains neuronal microtubule arrays by promoting microtubule rescue, preventing loss and maintaining polarity in C. elegans neurons.

This study shows that inhibiting histone deacetylases enhances neuronal resilience to stress by inducing a permissive transcriptional state and activating proteostasis pathways.

This study shows UNC-6/Netrin promotes both adhesion and directional growth in C. elegans axons through distinct mechanisms involving haptotaxis and chemotaxis.

The paper shows that dendritic growth is stochastic and ligand-free, while ligand binding inhibits growth and specifies shape in C. elegans neurons.

This study shows that cell cycle perturbation allows post-mitotic cells to maintain invasive behavior without exiting the cell cycle.

This study identifies SAD-1 kinase as a regulator of SYD-2/Liprin-α phase separation through phosphorylation, essential for presynaptic active zone assembly.

The paper investigates how Wnt signaling and contact-mediated repulsion regulate dendritic field sizes in C. elegans sensory neurons.

The paper introduces NanoDam, a method for tissue-specific transcription factor profiling in C. elegans using endogenous GFP-tagged TFs and nanobody-Dam fusions, identifying novel targets in specific cell types.

The paper investigates how NHR-67 and Groucho regulate the switch between proliferative and invasive states in C. elegans uterine cells.

The paper identifies two regulatory circuits that control the start and end times of dendritic arborization in nociceptive neurons through opposing regulation of the DMA-1 receptor.

This paper introduces a FLP-ON::TIR1 system for precise spatiotemporal protein degradation in C. elegans, showing it can drive efficient target protein degradation in specific cell types.

The paper reevaluates the relationship between EGL-43 and LIN-12 in C. elegans anchor cell invasion using a novel co-expression system and finds that LIN-12 is not required for AC proliferation after EGL-43 loss.

This study shows that mechanosensitive DEG/ENaC channels are essential for dendritic arbor morphogenesis in C. elegans by mediating mechanical feedback during ligand-mediated guidance.

This study identifies active zone proteins in C. elegans dopaminergic neurons and shows their role in synapse formation through regulated transport and clustering of synaptic vesicles.

This study identifies the THO nuclear export complex as critical for synaptic transcript export, synapse development, and neuronal survival in dopaminergic neurons across species.

This study identifies cla-1 as a novel C. elegans active zone gene, showing that specific isoforms regulate synapse development, synaptic vesicle clustering, and release.