Meng Carla Wang

Organelle Volume Facilitates Spindle Positioning During C. elegans Female Meiosis

The paper shows that organelle volume in C. elegans oocytes influences spindle positioning during meiosis by affecting the central ball of organelles.

Comparative proteomic quantification reveals novel longevity regulators

The paper compares five quantitative proteomic methods to identify high-confidence longevity regulators in C. elegans by analyzing IIS mutants.

Form and function of actin impacts actin health and aging.

This study investigates how actin structure and function affect aging in C. elegans and finds that actin dysfunction accelerates aging hallmarks and correlates with human age-related decline in gait speed.

Reconstituting Mouse Embryogenesis Ex Utero from Gastrulation to Fetal Development Reveals Maternally Independent Metabolic Programs

This paper uses ex utero culture to study mouse embryogenesis from gastrulation to fetal development, revealing metabolically independent programs and environmental influences on metabolic transitions.

COOKIE-Pro: Covalent Inhibitor Binding Kinetics Profiling on the Proteome Scale

COOKIE-Pro quantifies covalent inhibitor binding kinetics across the proteome, revealing off-targets and kinetic parameters for BTK inhibitors.

Lysosomes Signal through Epigenome to Regulate Longevity across Generations

The paper shows lysosomal pathways influence epigenetic marks in C. elegans, extending lifespan across generations through histone modifications.

TEMI: Tissue Expansion Mass Spectrometry Imaging

TEMI maps biomolecule distributions in tissues at single-cell resolution, revealing metabolic heterogeneity in tumors.

Development of a First-in-Class RIPK1 Degrader to Enhance Antitumor Immunity

This paper develops a first-in-class RIPK1 degrader, LD4172, which enhances antitumor immunity by promoting immunogenic cell death and sensitizing tumors to anti-PD1 therapy.

Cross-Tissue Coordination between SLC Nucleoside Transporters Regulates Reproduction in Caenorhabditis elegans

This study identifies SLC29A homologs in C. elegans that mediate nucleoside coordination between soma and germline, revealing guanosine as critical for reproduction.

Histone deacetylase inhibition expands cellular proteostasis repertoires to enhance neuronal stress resilience

This study shows that inhibiting histone deacetylases enhances neuronal resilience to stress by inducing a permissive transcriptional state and activating proteostasis pathways.

Chemical Induction of Longevity-Promoting Colanic Acid in the Host's Microbiota

This study shows that low-dose cephaloridine induces colanic acid production in gut bacteria, extending host lifespan in C. elegans and mice.

Aging Atlas Reveals Cell-Type-Specific Regulation of Pro-longevity Strategies

This study generates single-cell transcriptomic atlases of C. elegans across its lifespan under pro-longevity conditions to identify cell-type-specific aging mechanisms and regulatory changes.

Efficacy of longevity interventions in C. elegans is determined by early life activity of RNA splicing factors

The paper shows that early life activity of RNA splicing factors and lipid metabolism determine the efficacy of longevity interventions in C. elegans.

Optogenetic control of gut bacterial metabolism to promote longevity

This study uses optogenetic control to manipulate gut bacterial metabolism in C. elegans and shows that increased colanic acid production extends lifespan.

Escherichia coli Metabolite Profiling Leads to the Development of an RNA Interference Strain for Caenorhabditis elegans

The paper identifies specific bacterial metabolites affecting C. elegans physiology and develops an RNA interference strain to study genotype-phenotype interactions without microbial confounding.