NeurosciencebioRxivPreprint
Resolving the estrogen paradox in hereditary retinal degeneration: Esr1 activation suppresses Tnf-α signaling as a photoreceptor self-protection mechanism
Yuting Li, Yadi Li, Jiarui Luo…·Jie Yan
This study identifies Esr1 activation as a protective mechanism against neuroinflammation in retinal degeneration, showing it suppresses Tnf-α signaling and reduces photoreceptor death.
DOI 10.1101/2025.09.07.674682