Resolving the estrogen paradox in hereditary retinal degeneration: Esr1 activation suppresses Tnf-α signaling as a photoreceptor self-protection mechanism
Yuting Li, Yadi Li, Jiarui Luo, Lan Wang, Qianlu Yang, Qianxi Yang, Cong Duan, Wenrong Xu, Yujie Dong, Lei Kong, Yan Li, Wenjia Zhang, Kangwei Jiao, Zhijian Zhao, Christina Schwarz, , Jie Yan
This study identifies Esr1 activation as a protective mechanism against neuroinflammation in retinal degeneration, showing it suppresses Tnf-α signaling and reduces photoreceptor death.
bioRxiv · Sep 7, 2025 · PreprintNeuroscience