Jie Yan

This study identifies ANO6 as a scaffold at ER-mitochondria contacts that facilitates lipid sequestration and ferroptosis evasion in chemoresistant breast cancer.

This study investigates how PARP regulates calpain activity in rd1 mouse photoreceptors and identifies potential therapeutic targets for inherited retinal degenerations.

This study investigates the role of PPARs and PGC-1α in photoreceptor neuroprotection in rd1 mouse model of retinal degeneration, finding that their activation reduces photoreceptor death and PARP activity.

This study identifies Esr1 activation as a protective mechanism against neuroinflammation in retinal degeneration, showing it suppresses Tnf-α signaling and reduces photoreceptor death.

This study investigates the role of calcium signaling in photoreceptor cell death in IRD using mouse models and identifies calpain-2 as a key contributor to degeneration.

This study uses scRNA-seq to analyze metabolic changes in mouse retinal cells during degeneration, identifying Ca2+-signaling and MAPK pathway involvement.

This study shows that diltiazem enantiomers block Ca2+-influx in photoreceptors but do not prevent degeneration, challenging the role of Ca2+ in retinal degeneration.