A SUN1-ApoD feedback loop promotes cellular aging via microtubule-nuclear mechanotransduction
Mengqi Chen, Paige C. Wilson, Wenyao Yang, Yue Ma, Yutao Li, Xinluan Wang, Richard Lynn Bennett, Jonathan D. Licht, Gregg G. Gundersen, Wakam Chang
The paper identifies a SUN1-ApoD feedback loop that promotes cellular aging through microtubule-nuclear mechanotransduction by inducing aging-related phenotypes in fibroblasts and muscle.
bioRxiv · Sep 10, 2026 · PreprintCell Biology