Wakam Chang

The paper identifies a SUN1-ApoD feedback loop that promotes cellular aging through microtubule-nuclear mechanotransduction by inducing aging-related phenotypes in fibroblasts and muscle.

This study shows β-catenin drives apical-basal polarization and TE lineage commitment in mouse embryos in vitro and in vivo.

The paper shows that nuclear N-glycans modify INM proteins, regulate H3K9me3, and maintain genomic stability by interacting with SETDB1.

This study shows elevated SUN1 disrupts cell polarity by coupling microtubules to the nuclear lamina, affecting mechanical force transmission during aging.