Gregg G. Gundersen

The paper identifies a SUN1-ApoD feedback loop that promotes cellular aging through microtubule-nuclear mechanotransduction by inducing aging-related phenotypes in fibroblasts and muscle.

This study identifies KIF3AC and RCP as essential for recycling integrin from disassembled focal adhesions to promote polarized FA formation at the leading edge of migrating fibroblasts.

The paper shows the nucleus actively directs mechanical properties of actin cytoskeleton via FHOD-associated LINC complexes, and disruption causes cardiac hypertrophy.

This study identifies a dynamic nuclear-plasma membrane contact mediated by the LINC complex that maintains epithelial architecture through Src signaling.

This study shows elevated SUN1 disrupts cell polarity by coupling microtubules to the nuclear lamina, affecting mechanical force transmission during aging.

This study shows RhoA signaling has both inhibitory and stimulatory effects on axon development depending on timing, location, and downstream effectors.