Targeting Liver Epsins Ameliorates Dyslipidemia in Atherosclerosis through Inhibition of Proprotein Convertase Subtilisin/Kexin Type 9-Mediated Low-density Lipoprotein Receptor Degradation
Bo Zhu, Krishan Gupta, Kui Cui, Beibei Wang, Marina V. Malovichko, Kathryn S. Li, Hao Wu, Arulsamy Kulandaisamy, Bandana Singh, Jianing Gao, Scott Wong, Patricia G Yancey, Douglas B. Cowan, Da‐Zhi Wang, Sudha B. Biddinger, , Hong Chen
This study shows that targeting liver epsins reduces atherosclerosis by preventing PCSK9-mediated LDLR degradation and improving LDL-C clearance.
bioRxiv · Aug 26, 2024 · PreprintCell Biology