Novel Role of Endothelial CD45 in Regulating Endothelial-to-Mesenchymal Transition in Atherosclerosis
Qianman Peng, Arulsamy Kulandaisamy, Yao Wei Lu, Bo Zhu, Bandana Singh, Kui Cui, Jill Wylie‐Sears, Marina V. Malovichko, Scott Wong, Douglas B. Cowan, Masanori Aikawa, Sanjay Srivastava, Da‐Zhi Wang, Joyce E. Bischoff, Kaifu Chen, Hong Chen
This study shows that deleting CD45 in endothelial cells reduces atherosclerosis by inhibiting EndoMT and TGFβ signaling through increased FGFR2 and KLF2 expression.
bioRxiv · Sep 3, 2024 · PreprintCell Biology