Benzene metabolites increase vascular permeability by activating heat shock proteins and Rho GTPases
Igor N. Zelko, Ahtesham Hussain, Marina V. Malovichko…·Sanjay Srivastava
Author
University of LouisvilleORCID 0000-0003-2127-5858Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
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Igor N. Zelko, Ahtesham Hussain, Marina V. Malovichko…·Sanjay Srivastava
Igor N. Zelko, Marina V. Malovichko, Samantha A. McFall…·Sanjay Srivastava
This study shows that chronic inhaled benzene exposure worsens atherosclerosis in LDLR-KO mice by increasing T-cell proliferation and Th17 polarization, along with vascular smooth muscle cell changes.
Qianman Peng, Arulsamy Kulandaisamy, Yao Wei Lu…·Hong Chen
This study shows that deleting CD45 in endothelial cells reduces atherosclerosis by inhibiting EndoMT and TGFβ signaling through increased FGFR2 and KLF2 expression.
Bo Zhu, Krishan Gupta, Kui Cui…·Hong Chen
This study shows that targeting liver epsins reduces atherosclerosis by preventing PCSK9-mediated LDLR degradation and improving LDL-C clearance.
Hao Wu, Kui Cui, Bo Zhu…·Hong Chen
This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.