The anti-phage mechanism of a widespread trypsin-MBL module
Pingping Huang, Jingxian Liu, Lijie Guo, Dongyang Xu, Lingbo Shen Shen, Purui Yan, Tong Chen, Wenying Fei, Mengjun Cheng, Zhaoxing Li, Meiling Lü, Lei Zhang, Nannan Wu, Lian‐Wen Qi, Yibei Xiao, Meirong Chen
This study identifies a trypsin-MBL module as a bacterial immune effector that uses proteolytic activation to enable DNase activity against invading nucleic acids while preventing self-toxicity.
bioRxiv · Sep 3, 2025 · PreprintBiochemistry