Nannan Wu

CPDD adapts an autoregressive DNA language model for bidirectional phage genome modeling, achieving higher random-mask restoration accuracy and supporting fitness prediction and classification.

EvSpark improves decoding speed for hybrid DNA models by speculative decoding with parallel verification, achieving significant speedups across real and synthetic prompts.

The paper elucidates the molecular mechanism of the Avs2-trypsin-MBL system, revealing how phage terminase recognition triggers tetramerization and activation of the system for anti-phage defense.

This study identifies a trypsin-MBL module as a bacterial immune effector that uses proteolytic activation to enable DNase activity against invading nucleic acids while preventing self-toxicity.

This study identifies the parasubthalamic nucleus and its Tac1-expressing neurons as critical for active avoidance learning through optogenetic and imaging experiments.