Astrocytes express DMT1 and transferrin receptors, which transport iron thus activating Ca2+ signalling: possible role in neuroprotection against iron overload?
Maosheng Xia, Wenzheng Guan, Ming Hua Ji, Shuai Li, Zexiong Li, Beina Chen, Manman Zhang, Shanshan Liang, Binjie Chen, Wenliang Gong, Chengyi Dong, Gehua Wen, Xiaoni Zhan, Dianjun Zhang, Xinyu Li, , Baoman Li
This study investigates how iron ions affect calcium signaling in astrocytes through DMT1 and TFR, revealing mechanisms of neuroprotection against iron overload.
bioRxiv · Jul 6, 2020 · PreprintMolecular Biology