Shanshan Liang

Geometric-aware and interpretable deep learning for single-cell batch correction via explicit disentanglement and optimal transport

iDLC corrects single-cell batch effects by explicitly disentangling biological and technical features and aligning distributions with geometric constraints, outperforming existing methods in preserving biological structure.

Iatrogenic Iron Promotes Neurodegeneration and Activates Self-protection of Neural Cells against Exogenous Iron Attacks

This study investigates the impact of iron from metal implants on neural cells, finding that iron accumulation affects neuronal function and may increase neurodegeneration risk.

Astrocytes express DMT1 and transferrin receptors, which transport iron thus activating Ca2+ signalling: possible role in neuroprotection against iron overload?

This study investigates how iron ions affect calcium signaling in astrocytes through DMT1 and TFR, revealing mechanisms of neuroprotection against iron overload.

Sleep deprivation selectively down-regulates astrocytic 5-HT2B receptors and triggers depressive-like behaviors via stimulating P2X7 receptors

This study shows chronic sleep deprivation reduces astrocytic 5-HT2B receptors via P2X7 receptors, leading to depressive-like behaviors through increased arachidonic acid and PGE2 release.

Fluoxetine improves behavioural deficits induced by chronic alcohol addiction by alleviating RNA editing of 5-HT2C receptors in astrocytes

This study shows that fluoxetine alleviates alcohol addiction by reducing RNA editing of 5-HT2C receptors in astrocytes, thereby increasing ATP release and improving behavioral symptoms.