Author

Beina Chen

China Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Alexei VerkhratskyiD· 4 shared Baoman LiiD· 4 shared Maosheng XiaiD· 4 shared Shanshan LiangiD· 4 shared Chengyi Dong· 3 shared Dawei GuaniD· 3 shared Zexiong LiiD· 3 shared Binjie CheniD· 2 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Alexei VerkhratskyORCID

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4 papers

Recent·Most cited

Iatrogenic Iron Promotes Neurodegeneration and Activates Self-protection of Neural Cells against Exogenous Iron Attacks

Maosheng Xia, Shanshan Liang, Shuai Li, Ming Hua Ji, Beina Chen, Manman Zhang, Chengyi Dong, Binjie Chen, Wenliang Gong, Gehua Wen, Xiaoni Zhan, Dianjun Zhang, Xinyu Li, Yuefei Zhou, Dawei Guan, , Baoman Li

This study investigates the impact of iron from metal implants on neural cells, finding that iron accumulation affects neuronal function and may increase neurodegeneration risk.

Function · Jan 12, 2021Peer-reviewedNeuroscience

Astrocytes express DMT1 and transferrin receptors, which transport iron thus activating Ca2+ signalling: possible role in neuroprotection against iron overload?

Maosheng Xia, Wenzheng Guan, Ming Hua Ji, Shuai Li, Zexiong Li, Beina Chen, Manman Zhang, Shanshan Liang, Binjie Chen, Wenliang Gong, Chengyi Dong, Gehua Wen, Xiaoni Zhan, Dianjun Zhang, Xinyu Li, , Baoman Li

This study investigates how iron ions affect calcium signaling in astrocytes through DMT1 and TFR, revealing mechanisms of neuroprotection against iron overload.

bioRxiv · Jul 6, 2020 · PreprintMolecular Biology

Sleep deprivation selectively down-regulates astrocytic 5-HT2B receptors and triggers depressive-like behaviors via stimulating P2X7 receptors

Maosheng Xia, Zexiong Li, Shuai Li, Shanshan Liang, Xiaowei Li, Beina Chen, Manman Zhang, Chengyi Dong, Alexei Verkhratsky, Dawei Guan, Baoman Li

This study shows chronic sleep deprivation reduces astrocytic 5-HT2B receptors via P2X7 receptors, leading to depressive-like behaviors through increased arachidonic acid and PGE2 release.

Neuroscience Bulletin · Jun 6, 2020Peer-reviewedNeuroscience

Fluoxetine improves behavioural deficits induced by chronic alcohol addiction by alleviating RNA editing of 5-HT2C receptors in astrocytes

Zexiong Li, Yan Lü, Shanshan Liang, Shuai Li, Beina Chen, Manman Zhang, Maosheng Xia, Dawei Guan, Alexei Verkhratsky, Baoman Li

This study shows that fluoxetine alleviates alcohol addiction by reducing RNA editing of 5-HT2C receptors in astrocytes, thereby increasing ATP release and improving behavioral symptoms.

Neurochemistry International · Jan 20, 2020Peer-reviewedNeuroscience