Human hip osteoarthritis-associated Chadl variant induces intervertebral disc degeneration in mice
Kimheak Sao, Bryn Mallon, Jacqueline Shine, Anastasia Mavridis, Elena V. Filippova, Jack R. Felkner, Carson D. Shepler, Tanner M. Orders, Susan D’Costa, William A. Cowan, Brian O. Diekman, Makarand V. Risbud
This study shows that a human hip OA-associated Chadl variant causes intervertebral disc degeneration in mice, with changes in ECM and biomechanics.
bioRxiv · Jun 6, 2026 · PreprintCell Biology