Susan D’Costa

This study uses single-cell RNA sequencing to analyze how fibronectin fragment treatment alters chondrocyte states and transcriptional programs in primary human cells.

This study shows that a human hip OA-associated Chadl variant causes intervertebral disc degeneration in mice, with changes in ECM and biomechanics.

This paper uses CRISPR/Cas9 to edit bovine satellite cells to remove the alpha-gal epitope, creating AGS-compatible cultivated meat with reduced allergenic potential.

The paper identifies OA risk genes by integrating eQTLs, chromatin accessibility, and 3D chromatin structure in human chondrocytes, revealing 13 putative risk genes, 10 of which are novel.

The paper identifies response splicing QTLs in human chondrocytes and links them to osteoarthritis risk genes through alternative splicing analysis.

The paper identifies 47 expression-modulating variants in AD-associated loci by analyzing their impact in immune cells under different inflammatory conditions.

The paper identifies 56 putative OA risk genes by integrating GWAS, chromatin structure, and RNA-seq data in chondrocytes, with SOCS2 as a novel target gene.