Author

Kimheak Sao

Thomas Jefferson UniversityORCID 0000-0002-9164-1529Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:imaging· 1

Frequent Co-Authors

Makarand V. RisbudiD· 2 shared Anastasia Mavridis· 1 shared Brian O. DiekmaniD· 1 shared Bryn Mallon· 1 shared Carson D. Shepler· 1 shared Elena V. Filippova· 1 shared Jack R. FelkneriD· 1 shared Jacqueline ShineiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Makarand V. RisbudORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJun 6, 2026

Human hip osteoarthritis-associated Chadl variant induces intervertebral disc degeneration in mice

Kimheak Sao, Bryn Mallon, Jacqueline Shine…·Makarand V. Risbud

This study shows that a human hip OA-associated Chadl variant causes intervertebral disc degeneration in mice, with changes in ECM and biomechanics.

DOI 10.64898/2026.06.04.730159

𝕏 PostBluesky

Cell BiologyCell Death and DiseasePeer-reviewedOct 6, 2025

SDC4 drives fibrotic remodeling of the intervertebral disc under altered spinal loading

Kimheak Sao, Makarand V. Risbud

This study shows that SDC4 deletion protects against disc degeneration in mice under increased spinal flexion by preserving notochordal features and modulating proteomic pathways.

6 citations

mouseproteomics

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