Jacqueline Shine

Mapping the response of primary human chondrocytes to an osteoarthritis-relevant stimulus by single-cell RNA sequencing

This study uses single-cell RNA sequencing to analyze how fibronectin fragment treatment alters chondrocyte states and transcriptional programs in primary human cells.

Sex differences in senescence burden within human osteoarthritic synovial fibroblasts

This study finds that female OA synovial fibroblasts show higher senescence markers and reduced oxidative stress response compared to males.

Human hip osteoarthritis-associated Chadl variant induces intervertebral disc degeneration in mice

This study shows that a human hip OA-associated Chadl variant causes intervertebral disc degeneration in mice, with changes in ECM and biomechanics.

CRISPR-mediated engineering of bovine satellite cells for Alpha-Gal Syndrome-compatible cultivated meat

This paper uses CRISPR/Cas9 to edit bovine satellite cells to remove the alpha-gal epitope, creating AGS-compatible cultivated meat with reduced allergenic potential.

Comparative whole-genome analyses of articular chondrocytes and skin fibroblasts reveal distinct genome instability landscapes in mesenchymal cell types

This study compares genome instability in articular chondrocytes and skin fibroblasts using whole-genome sequencing, revealing distinct mutation patterns and mutagenic mechanisms between the two cell types.

Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk

The paper identifies OA risk genes by integrating eQTLs, chromatin accessibility, and 3D chromatin structure in human chondrocytes, revealing 13 putative risk genes, 10 of which are novel.

Response splicing QTLs in primary human chondrocytes identifies putative osteoarthritis risk genes

The paper identifies response splicing QTLs in human chondrocytes and links them to osteoarthritis risk genes through alternative splicing analysis.