Brian O. Diekman

This study identifies ZNF865 as a regulator of cell senescence and DNA damage in intervertebral discs, showing its role in back pain and potential as a therapeutic target.

This study uses single-cell RNA sequencing to analyze how fibronectin fragment treatment alters chondrocyte states and transcriptional programs in primary human cells.

This study finds that female OA synovial fibroblasts show higher senescence markers and reduced oxidative stress response compared to males.

This study shows that a human hip OA-associated Chadl variant causes intervertebral disc degeneration in mice, with changes in ECM and biomechanics.

This paper uses CRISPR/Cas9 to edit bovine satellite cells to remove the alpha-gal epitope, creating AGS-compatible cultivated meat with reduced allergenic potential.

This study compares genome instability in articular chondrocytes and skin fibroblasts using whole-genome sequencing, revealing distinct mutation patterns and mutagenic mechanisms between the two cell types.

The paper uses single-cell proteomics to identify two distinct senescence subpopulations with different SASP characteristics during long-term stress.

The paper identifies OA risk genes by integrating eQTLs, chromatin accessibility, and 3D chromatin structure in human chondrocytes, revealing 13 putative risk genes, 10 of which are novel.

The paper identifies response splicing QTLs in human chondrocytes and links them to osteoarthritis risk genes through alternative splicing analysis.

The paper identifies 56 putative OA risk genes by integrating GWAS, chromatin structure, and RNA-seq data in chondrocytes, with SOCS2 as a novel target gene.