Liquefaction of the brain following stroke shares a similar molecular and morphological profile with atherosclerosis and mediates secondary neurodegeneration in an osteopontin dependent mechanism
Amanda G. Chung, Jennifer Beischel Frye, Jacob C. Zbesko, Eleni Constantopoulos, Megan I. Hayes, Anna G. Figueroa, Danielle A. Becktel, William A. Day, John P. Konhilas, Brian S. McKay, Thuy‐Vi V. Nguyen, Kristian P. Doyle
This paper compares ischemic inflammation in the heart and brain, finding a second inflammatory wave in the brain post-stroke linked to cholesterol crystals and osteopontin, which drives secondary neurodegeneration.
eNeuro · Sep 1, 2018Peer-reviewedNeuroscience